Stavroula Kyriazi1, David J. Collins1, Robert L. Davidson1, Veronica A. Morgan1, Sharon L. Giles1, Catherine J. Simpkin1, Stan B. Kaye2, Nandita M. deSouza1
1Cancer Imaging Centre, Institute of Cancer Research & The Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom; 2Gynaecological Oncology, Institute of Cancer Research & The Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom
This study investigates ADC histogram-derived parameters as predictive biomarkers of chemotherapy response in forty-five patients with advanced ovarian cancer. Mean ADC, 10th, 25th, 50th, 75th and 90th centile points (C10, C25, C50, C75 and C90), and histogram skew were calculated in 126 primary ovarian and metastatic peritoneal, omental and visceral lesions, before and after the 1st, 3rd and 6th cycle of treatment. A linear mixed model was used to analyze differences between responders and non-responders across timepoints . Morphological (RECIST) and biochemical (serum CA125) response were associated with an early and sustained increase of ADC values and decrease of skew (right histogram shift and tendency to normalization). The parameter with the highest discriminant accuracy was percentage C25 change (AUC=.791 and .818 post-1st and -3rd cycle respectively).