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Abstract #0348

Propagation of Probabilistic Tractography of the Optic Radiation for Neuronavigation in Epilepsy Surgery

Gavin P. Winston1, Pankaj Daga2, Jason Stretton1, Marc Modat2, Mark R. Symms1, Andrew W. McEvoy3, Sebastien Ourselin2, John S. Duncan1,3

1UCL Institute of Neurology, London, United Kingdom; 2UCL Centre for Medical Image Computing, London, United Kingdom; 3National Hospital for Neurology & Neurosurgery, London, United Kingdom

Anterior temporal lobe resection (ATLR) is an effective treatment for temporal lobe epilepsy refractory to medication, but leads to a visual field deficit in between 52% and 100% of patients. Probabilistic tractography is required to accurately depict Meyer's loop of the optic radiation, but cannot be performed in real-time. Propagation of preoperative probabilistic tractography to intraoperative images using non-linear registration techniques accounting for brain shift and deformation and subsequent integration into the neuronavagional suite should improve the outcome from epilepsy surgery. Such a technique is described and validated with outcome in patients undergoing ATLR using pre- and postoperative images.