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Abstract #0389

Magnetic Resonance Elastography Measurements of Viscosity: A Novel Biomarker For Human Hepatic Tumor Malignancy?

Sabrina Doblas1, Philippe Garteiser1, Nathalie Haddad1,2, Jean-Luc Daire1,2, Mathilde Wagner1,2, Helena Leitao2,3, Valrie Vilgrain1,2, Ralph Sinkus1, Bernard E. Van Beers1,2

1Centre de Recherche Biomdicale Bichat-Beaujon, INSERM U773, Clichy, France; 2Department of Radiology, Beaujon University Hospital, University Paris Diderot, Clichy, France; 3Department of Radiology, Hospitais de Universidade de Coimbra, Coimbra, Portugal

The accurate and non-invasive determination of the degree of malignancy of a tumor remains a clinical challenge. To determine if magnetic resonance elastography (MRE) could represent a novel non-invasive diagnosis tool, tissue elasticity and viscosity measurements were conducted in a cohort of 76 patients with histologically confirmed hepatic lesions (42 benign and 37 malignant). Malignant tumors, especially HCC, were found to be more viscous than benign lesions. This study shows that MRE measurements of viscosity could be a promising tool for tumor malignancy detection, and can help characterizing some tumor types.