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Abstract #0391

Paradoxical Correlation between Mrp2 Expression & Fibrosis

Natsuko Tsuda1, Osamu Matsui2

1Medical Affairs , Bayer Yakuhin, Ltd., Osaka, Japan; 2Department of Radiology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan

We compared the transporter (oatp1 and mrp2) expression and signal profile on the Gd-EOB-DTPA-enhanced MRI between NASH and cirrhotic liver induced in rats, and investigated the correlation of the transporter expression and fibrosis rate in both diseases. There was no significant difference in the oatp1 expression between the cirrhosis and NASH groups; whereas, the mrp2 expression in the TAA group increased in comparison with the NASH and control groups. In addition, there was a paradoxical correlation between the fibrosis rate and mrp2 expression. The signal enhancement on Gd-EOB-DTPA-enhanced MRI would reflect the transporter expression in NASH and cirrhosis.