Abstract #0401

Medullar & Thalamic Metabolic Alterations Following Spinal Cord Injury (SCI): A Preliminary Mice Study, Combining Early & Longitudinal Follow-Ups using High-Spatially Resolved MRS & DTI At High Field

Mohamed Tachrount¹, Guillaume Duhamel¹, Andr Maues de Paula², Jrme Laurin³, Tanguy Marqueste³, Patrick Decherchi³, Patrick J. Cozzone¹, Virginie Callot¹

¹Centre de Rsonance Magntique Biologique et Mdicale (CRMBM, UMR 6612, CNRS), Facult de Mdecine, Universit de la Mditerrane, Marseille, France; ²Service dAnatomie Pathologique, Hpital de la Timone, Marseille, France; ³Institut des Sciences du Mouvement (ISM, UMR CNRS 6233), Facult des sciences, Universit de la Mditerrane, Marseille, France

In this preliminary study, we used high-spatially resolved 1H-MRS, in combination with refine adjustments and dedicated quantification, to examine medullar and thalamic metabolic alterations following spinal cord injury in mice, from the very first days to six weeks after injury. Multi-slice DTI were concomitantly acquired at each time-point and immuno-histochemistry was performed to investigate correlation with both MRS and DTI data.