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Abstract #0401

Medullar & Thalamic Metabolic Alterations Following Spinal Cord Injury (SCI): A Preliminary Mice Study, Combining Early & Longitudinal Follow-Ups using High-Spatially Resolved MRS & DTI At High Field

Mohamed Tachrount1, Guillaume Duhamel1, Andr Maues de Paula2, Jrme Laurin3, Tanguy Marqueste3, Patrick Decherchi3, Patrick J. Cozzone1, Virginie Callot1

1Centre de Rsonance Magntique Biologique et Mdicale (CRMBM, UMR 6612, CNRS), Facult de Mdecine, Universit de la Mditerrane, Marseille, France; 2Service dAnatomie Pathologique, Hpital de la Timone, Marseille, France; 3Institut des Sciences du Mouvement (ISM, UMR CNRS 6233), Facult des sciences, Universit de la Mditerrane, Marseille, France

In this preliminary study, we used high-spatially resolved 1H-MRS, in combination with refine adjustments and dedicated quantification, to examine medullar and thalamic metabolic alterations following spinal cord injury in mice, from the very first days to six weeks after injury. Multi-slice DTI were concomitantly acquired at each time-point and immuno-histochemistry was performed to investigate correlation with both MRS and DTI data.