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Abstract #0419

In Vivo T2 & T1rho Mapping of Rabbit Disc using Spin-Lock Sequence at 3T

Chan Hong Moon1, Lloydine Jacobs2,3, Jung-Hwan Kim1, Xiang He1, James Kang2,3, Kyongtae Ty Bae1

1Radiology, University of Pittsburgh, Pittsburgh, PA, USA; 2Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA; 3Ferguson Laboratory for Orthopaedic & Spine Research

We successfully obtained high-resolution, high-contrast T2 and T1rho images and measured T2 and T1rho in normal rabbit spine discs using in-house dual-tuned RF coil and SL sequence at 3T. Further study is necessary to demonstrate difference in T2 and T1rho between normal and degenerative disc models in rabbits in order to validate these imaging biomarkers for degenerative disc disease.