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Abstract #0421

In Vivo Sodium MRI of Intervertebral Disc At 7T

Chenyang Wang1,2, Mark Elliott3, Thomas Connick3, Walter Witshcey3, Joseph Calabro4, Ari Borthakur3, Ravinder Reddy3

1School of Medicine, Yale University, New Haven, CT, USA; 2Bioengineering, University of Pennsylvania, Philadelphia, PA, USA; 3Radiology, University of Pennsylvania, Philadelphia, PA, USA; 4Siemens Medical Solutions, USA

Intervertebral disc degeneration is a common and sometimes painful condition. The initial sign of intervertebral disc degeneration involves the breakdown of proteoglycans and the accompanying depletion of Na+. Sodium MRI has previously been used to study the depletion of Na+ in intervertebral disc ex vivo. In this study, we carried out in vivo sodium MRI of intervertebral disc on a 7 T MRI scanner. The tissue [Na+] value calculated from the sodium MR images were correlated with intervertebral disc degenerative grade, in order to elucidate the trend in [Na+] content in IVDs undergoing degeneration.