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Abstract #0426

Initial Results from Baseline Structural & Computational Biomechanics MRI Study in Postmenopausal Women

Yusuf A. Bhagat1, Chamith S. Rajapakse1, Jeremy F. Magland1, Michael J. Wald1, Theresa M. Scattergood2, Peter J. Snyder2, Felix W. Wehrli1

1Laboratory for Structural NMR Imaging, University of Pennsylvania, Philadelphia, PA, USA; 2Division of Endocrinology, Diabetes & Metabolism, University of Pennsylvania, Philadelphia, PA, USA

Recent advances in high-resolution structural imaging of trabecular and cortical bone and the use of these data as input into micro-finite-element (FE) models have shown potential for assessing the effect of treatment in patients with osteoporosis. Here, we report initial baseline and select follow-up data in an ongoing investigation of women with low bone density (N=30) receiving either zoledronic acid or teriparatide, conducted at 3T and 7T. The baseline data show moderate associations with pQCT bone density while FE-derived axial stiffness is strongly correlated with bone volume fraction at the same site. Finally, repeat data in select subjects indicate large anabolic effects.