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Abstract #0431

BOLD Resting State Networks in Adults with Complete Callosal Agenesis

Julian Michael Tyszka1, Lynn K. Paul2, Ralph Adolphs1,2

1Biology, California Institute of Technology, Pasadena, CA, USA; 2Humanities & Social Sciences, California Institute of Technology, Pasadena, CA, USA

The impact of agenesis of the corpus callosum on resting state connectivity in the human brain is largely unknown. In this study, we apply well-established probabilistic independent component analysis (PICA) methods to BOLD fMRI time course data in a minimum deformation space to identify spatial independent components unique to and absent in callosal agenesis. Over 80% of neurotypical BOLD resting state networks identified by group PICA are preserved in adult AgCC subjects suggesting that compensatory networks established during brain development play a major role in this condition.