Abstract #0439

Assessment of Rhabdomyolysis-Induced Acute Kidney Injury (AKI) in Mice using Hemodynamic Response Imaging (HRI)

Zohar Milman¹, Jonathan Axelrod¹, Samuel Heyman², Nathalie Corchia¹, Rinat Abramovitch¹

¹The Goldyne Savad Institute for Gene Therapy, Hadassah Hebrew University Medical Center, Jerusalem, Israel; ²Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel

The pathophysiology of rhabdomyolysis-induced AKI is complex and incompletely understood, however hypoxia is one of the factors thought to contribute. The use of MRI for the diagnosis and assessment of AKI is expanding; however, contrast-enhanced studies are limited. We studied the feasibility of HRI, an MRI method, based on BOLD fMRI, combined with hypercapnia and hyperoxia challenges, for monitoring changes in kidney perfusion and hemodynamics during AKI in mice. Our results indicate high correlation between kidney dysfunction and decreased perfusion as measured by HRI. This technique provides supplementary information regarding kidney perfusion, hemodynamics and blood vessels reactivity during evolving AKI.