Abstract #0442

Establishment of a Renal Oxygen Transit Model Based on BOLD MRI

Jeff Lei Zhang¹, Lizette Warner², Henry Rusinek¹, Hersh Chandarana¹, Pippa Storey¹, Eric E. Sigmund¹, Qun Chen¹, Lilach O. Lerman³, Vivian S. Lee¹

¹Department of Radiology, New York University, New York, NY, USA; ²MR Development, Methods & Applications Software, Philips Healthcare, Highland Hts, OH, USA; ³Division of Nephrology & Hypertension, Mayo Clinic, Rochester, MN, USA

Renal functional BOLD imaging has shown to be capable of identifying diuretic-induced change in oxygen level in renal medulla. This study proposed an oxygen kinetic model to determine tissue pO2 from BOLD data. Using a subset of experimental BOLD and O2 probe measurements from pig kidneys we first fitted oxygen permeability and regional hematocrit. Using these fitted values, we then tested the performance of the model to predict cortical and medullary pO2 based on BOLD MRI measurements using a different set of experimental data which included direct probe measurements of tissue pO2.