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Abstract #0442

Establishment of a Renal Oxygen Transit Model Based on BOLD MRI

Jeff Lei Zhang1, Lizette Warner2, Henry Rusinek1, Hersh Chandarana1, Pippa Storey1, Eric E. Sigmund1, Qun Chen1, Lilach O. Lerman3, Vivian S. Lee1

1Department of Radiology, New York University, New York, NY, USA; 2MR Development, Methods & Applications Software, Philips Healthcare, Highland Hts, OH, USA; 3Division of Nephrology & Hypertension, Mayo Clinic, Rochester, MN, USA

Renal functional BOLD imaging has shown to be capable of identifying diuretic-induced change in oxygen level in renal medulla. This study proposed an oxygen kinetic model to determine tissue pO2 from BOLD data. Using a subset of experimental BOLD and O2 probe measurements from pig kidneys we first fitted oxygen permeability and regional hematocrit. Using these fitted values, we then tested the performance of the model to predict cortical and medullary pO2 based on BOLD MRI measurements using a different set of experimental data which included direct probe measurements of tissue pO2.