MRI of Cells & Mice At 1 & 7Tesla with Gd-Targeting Agents: When the Low Field is Better!

Simonetta Geninatti-Crich¹, Diego Alberti¹, Ibolya Szabo¹, Dario Longo¹, Silvio Aime¹

A comparison between the efficiency of slowly moving macromolecular MRI imaging probes at 1 and 7 Tesla was carried out using Gd-loaded/LDL (Low Density Lipoproteins) adducts consisting of 250 Gd amphiphilic complexes incorporated in the lipophilic LDL particles. The sensitivity enhancement obtained at 1 Tesla of B16 melanoma cells labeled with Gd-AAZTAC17/LDL adduct is several times higher than that attained at higher fields.