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Abstract #0456

MRI of Cells & Mice At 1 & 7Tesla with Gd-Targeting Agents: When the Low Field is Better!

Simonetta Geninatti-Crich1, Diego Alberti1, Ibolya Szabo1, Dario Longo1, Silvio Aime1

1University of Torino, Torino, Italy

A comparison between the efficiency of slowly moving macromolecular MRI imaging probes at 1 and 7 Tesla was carried out using Gd-loaded/LDL (Low Density Lipoproteins) adducts consisting of 250 Gd amphiphilic complexes incorporated in the lipophilic LDL particles. The sensitivity enhancement obtained at 1 Tesla of B16 melanoma cells labeled with Gd-AAZTAC17/LDL adduct is several times higher than that attained at higher fields.