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Abstract #0458

Ischemic Penumbra in Acute MCA Stroke: Comparison of the PWI-DWI Mismatch & the ADC-Based NEURINFARCT Methods

Aurelie Drier1,2, Thomas Tourdias3, Igor Sibon4, Yohan Attal5, Gurkan Mutlu6, Stphane Lehricy1,2, Yves Samson6, Jacques Chiras1, Didier Dormont1, Jean-Marc Orgogozo4, Vincent Dousset3, Charlotte Rosso6

1Neuroradiology, Piti Salptrire Hospital, Paris, France; 2Centre de NeuroImagerie de Recherche - CENIR,CRICM U795, Paris, France; 3Neuroradiology, CHU Pellegrin, Bordeaux, France; 4Neurology, CHU Pellegrin, Bordeaux, France; 5CRICM, CNRS, UMR7225 quipe NEMESIS, Paris, France; 6Urgences crbro-vasculaires, Piti Salptrire Hospital, Paris, France

The MRI prediction of the risk of infarct growth is essential for decision making in acute stroke treatment. A method only based on DWI and ADC maps has been recently developped to identify the at-risk tissue. In this study, this new method is compared to the gold standard, the PWI/DWI mismatch. It is as efficient as the PWI/DWI mismatch for the prediction of infarct growth and more efficient for the prediction of infarct volume. The ADC-based methods performances are similar during and after the therapeutic window (4H30) whereas they are significantly lower after 4h30 after stroke onset with the PWI/DWI mismatch.