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Abstract #0511

Potential of Diffusion MRI As a Biomarker of Low-Risk DCIS

Mami Iima1, Denis Le Bihan2,3, Tomohisa Okada1, Koji Fujimoto1, Shotaro Kanao1, Shiro Tanaka4, Kaori Togashi1

1Dept. of Diagnostic Radiology, Kyoto University Graduate School of Medicine, Kyoto, Japan; 2Human Brain Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan; 3Neurospin, CEA-Saclay Center, Gif-sur-Yvette Cedex, France; 4The Translational Research Center, Kyoto University Hospital, Kyoto, Japan

This study included 18 patients who underwent breast MRI examinations at 1.5T. The MRI protocol contained diffusion-weighted images with b values of 0 and 1,000 s/mm2. The ADC value of high-grade DCIS was significantly lower than that of low-grade DCIS (p =0.01), and there was a significant linear positive trend between ADC and lesion stage (p <0.01). Above ADC threshold of 1.3 x 10-3 mm/s for the diagnosis of high-grade DCIS, all DCIS lesions were identified as low-grade DCIS with a 100% specificity. Quantitative DWI could be used to identify patients with low-stage DCIS with very high specificity.