Abstract #0513

High-Speed MR Spectroscopic Imaging of Total Choline in Breast Cancer & Healthy Controls at 3T: A Feasibility Study

Chenguang Zhao¹, Patrick Bolan², Melanie Royce³, Lavneeth Lakkadi², Sang-Joon Lee⁴, Steve Eberhard⁵, Stefan Posse^1,6

¹Neurology, University of New Mexico, Albuquerque, NM, USA; ²CMRR, University of Minnesota, Minneapolis, MN, USA; ³Medical Oncology, University of New Mexico, Albuquerque, NM, USA; ⁴Internal Medicine, University of New Mexico, Albuquerque, NM, USA; ⁵Radiology, University of New Mexico, Albuquerque, NM, USA; ⁶Electrical & Computer Engineering, University of New Mexico, Albuquerque, NM, USA

This study investigates the feasibility of using high-speed Proton-Echo-Planar-Spectroscopic-Imaging (PEPSI) to map a key biomarker, total Choline (tCho) in breast cancer. In a patient with locally advanced infiltrating ductal carcinoma, the tCho concentration measured in 9 voxels was 14.65.4 mmol/kg using PEPSI vs. 12.78.0 mmol/kg using PRESS CSI. In a group of healthy controls, the slice averaged tCho concentration measured using PEPSI was 0.480.2 mmol/kg. This was consistent with measurement using PRESS CSI (0.56 0.44mmol/kg) and PRESS single voxel Spectroscopy (0.69 0.6 mmol/kg).