Abstract #0541

Validation of Ventilation- & Perfusion-Weighted Fourier Decomposition MRI with Hyperpolarized 3He-MRI & Dynamic Contrast-Enhanced MRI in An Animal Experiment

Grzegorz Bauman¹, Alexander Scholz², Julien Rivoire², Maxim Terekhov², Janet Friedrich², Andre de Oliveira³, Wolfhard Semmler¹, Laura M. Schreiber², Michael Puderbach⁴

¹Division of Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany; ²Department of Radiology, Section of Medical Physics, Johannes Gutenberg University Medical Center, Mainz, Germany; ³Siemens Healthcare, Erlangen, Germany; ⁴Division of Radiology, German Cancer Research Center, Heidelberg, Germany

Regardless of physical and technical difficulties, MRI offers a broad spectrum of methods for the relative or absolute evaluation of the lung function. Recently, a technique of Fourier decomposition MRI (FD-MRI) was proposed to obtain regional lung perfusion and ventilation-related information during a single acquisition series. FD-MRI is based on a non-invasive, untriggered and contrast media free image acquisitions. The purpose of this study was the validation of this lung functional imaging technique against Dynamic Contrast-Enhanced MRI and hyperpolarized ³He-MRI in an animal experiment under controlled conditions.