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Abstract #0541

Validation of Ventilation- & Perfusion-Weighted Fourier Decomposition MRI with Hyperpolarized 3He-MRI & Dynamic Contrast-Enhanced MRI in An Animal Experiment

Grzegorz Bauman1, Alexander Scholz2, Julien Rivoire2, Maxim Terekhov2, Janet Friedrich2, Andre de Oliveira3, Wolfhard Semmler1, Laura M. Schreiber2, Michael Puderbach4

1Division of Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany; 2Department of Radiology, Section of Medical Physics, Johannes Gutenberg University Medical Center, Mainz, Germany; 3Siemens Healthcare, Erlangen, Germany; 4Division of Radiology, German Cancer Research Center, Heidelberg, Germany

Regardless of physical and technical difficulties, MRI offers a broad spectrum of methods for the relative or absolute evaluation of the lung function. Recently, a technique of Fourier decomposition MRI (FD-MRI) was proposed to obtain regional lung perfusion and ventilation-related information during a single acquisition series. FD-MRI is based on a non-invasive, untriggered and contrast media free image acquisitions. The purpose of this study was the validation of this lung functional imaging technique against Dynamic Contrast-Enhanced MRI and hyperpolarized 3He-MRI in an animal experiment under controlled conditions.