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Abstract #0555

In Vivo Dynamic Contrast Enhanced MRI & Histopathological Assessment of Tumor Angiogenesis in Luminal-Like & Basal-Like Breast Cancer Xenografts

Else Marie Huuse1, Siver Andre Moestue1, Tone Frost Bathen1, Anna Bofin2, Gunhild Mari Mlandsmo3, Lars A. Akslen4, Olav Engebraaten3,5, Ingrid S. Gribbestad1

1Department of Circulation & Medical Imaging, Norwegian University of Science & Tehcnology (NTNU), Trondheim, Norway; 2Department of Laboratory Medicine, Children's & Women's Health, NTNU, Trondheim, Norway; 3Department of Oncology & Department of Tumor Biology, Oslo University Hospital, Oslo, Norway; 4The Gade Institute, Section for Pathology, University of Bergen, Bergen, Norway; 5Institute for Clinical Medicine, University of Oslo, Oslo, Norway

Two new breast cancer xenograft models, reflecting luminal-like (MAS98.06, ER+, low growth rate) and basal-like (MAS98.12, ER-, high growth rate) subgroups, have recently been established by direct transplantation of primary tumor tissue. The differences in tumor vasculature and angiogenesis, and the effect of tumor volume were investigated using DCE-MRI and histopathological measures. The results showed a significantly higher Ktrans, vp and vascular proliferation index in the aggressive basal-like tumors compared to the luminal-like tumors. Additionally, the results showed a positive correlation between vp and micro vessel density and a negative correlation between vp and hypoxia and between Ktrans and hypoxia.