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Abstract #0558

Metabolic Profiling of Primary & Recurrent Mammary Gland Tumors in an Inducible Her2/neu Breast Cancer Mouse Model using 1H MRS

Dania Daye1, James Alvarez2,3, Suzanne Wehrli4, Mitchell Schnall5, Lewis Chodosh2,3

1Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA; 2Department of Cancer Biology, University of Pennsylvania; 3Abramson Family Cancer Research Institute, University of Pennsylvania; 4Nuclear Magnetic Resonance Core Facility, Children's Hospital of Philadelphia; 5Department of Radiology, University of Pennsylvania

Breast cancer is the most commonly diagnosed malignancy in women and is the second leading cause of cancer-related death in the female population worldwide. Cancer recurrence represents the principal cause of death from this disease. To dissect the mechanisms implicated in recurrence, our lab has developed an inducible transgenic mouse model that accurately reproduces key features of the natural history of human breast cancer progression: primary tumor development, tumor dormancy and recurrence. The goal of this study was to investigate the role of 1H MRS metabolic profiling as a potential breast cancer progression marker using this model.