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Abstract #0588

Glutamate Level in the Frontal Cortex Decreases During Young Adulthood

Anouk Marsman1, Dennis Klomp2, Jannie Wijnen2, Martijn Van den Heuvel1, Vincent Boer2, Peter Luijten2, Hilleke Hulshoff Pol1

1Psychiatry, University Medical Center Utrecht, Utrecht, Netherlands; 2Radiology, University Medical Center Utrecht, Utrecht, Netherlands

Glutamate is the major excitatory neurotransmitter in the central nervous system and is involved in functions that alter with age. Using 1H-MRS (STEAM) at 7 Tesla, glutamate was measured in the medial frontal cortex of young adults, in which a decrease in glutamate concentration with increasing age was found. The decrease in glutamate concentration is in line with the gray matter thinning in medial frontal cortex in young adulthood. However, the change in glutamate is larger than the gray matter change, therefore we postulate that the observed effect is due to physiological changes rather than anatomical changes.