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Abstract #0604

Multiple Sclerosis Alters Intra-cellular Sodium Concentration & Intra-cellular Volume Fraction: An In-Vivo 7T MRI study

Lazar Fleysher1, Niels Oesingmann2, Ryan Brown1, Hina Jaggi1, Graham Wiggins1, Daniel Sodickson1, Joseph Herbert3, Matilde Inglese1

1Radiology, NYU School of Medicine, New York, USA; 2Siemens Medical Solutions USA, Malvern, PA, USA; 3Neurology, NYU School of Medicine, New York, USA

Intracellular Sodium Concentration (ISC) and Intracellular Sodium Volume Fraction (ISVF) are often used as operational measures of tissue viability. Elevated brain tissue sodium concentration (TSC) has been reported previously in MS patients. However, TSC is sensitive but not specific to variations in ISC and ISVF. In this work, we employ single- (SQ) and triple-quantum-filtered (TQF) sodium MRI at 7T to evaluate ISC and ISVF in MS patients. We found that ISCs in the MS patients are higher than in healthy controls indicating accumulation of intracellular sodium. In addition, we observed that the patients ISFVs are lower than those of healthy controls indicating loss of the intracellular volume.