Christian Langkammer1, Michael Khalil1, Christian Enzinger1, Mirja Wallner-Blazek1, Margit Jehna1, Siegried Fuchs1, Franz Fazekas1, Stefan Ropele1
This study assessed iron accumulation in white matter lesions of 116 MS patients using R2* relaxometry. Intralesional R2* rates were compared to normal white matter of age matched controls and were related to clinical parameters. They showed a negative correlation with T2 lesion load and a positive correlation with brain atrophy and were significantly decreased in MS patients compared to white matter R2* rates of controls. The results of this work do not support expectations of increased iron accumulation in MS lesions, but rather indicate lower levels compared to normal white matter.