Mao-Yuan Su1, Vin-cent Wu2,3, Yen-Hung Line2,3, Hsi-Yu Yu4, Wen-Yieh Isaac Tseng1,5
1Medical Imaging, National Taiwan University Hosptial, Taipei, Taiwan; 2Internal Medicine, National Taiwan University Hosptial, Taipei, Taiwan; 3TAIPAI study group; 4Sugery, National Taiwan University Hosptial, Taipei, Taiwan; 5Center for Optoelectronic Biomedicine, National Taiwan University College of Medicine, Taipei, Taiwan
We used quantitative late gadolinium enhancement (LGE) to detect microscopic myocardial fibrosis and study its relationships with the chamber stiffness of the left ventricle (LV). As compared to the normal subjects, patients with primary hyperaldosteronism (PA) had significantly increased enhancement value (EV) (0.450.07 vs. 0.350.09; p=0.016). The EV was significantly correlated with the plasma aldosterone level (r=0.48; p=0.031) and tdec (index of chamber stiffness derived from cine MRI; r= -0.55; p=0.042). In conclusion, quantitative LGE MRI can indicate the degree of microscopic myocardial fibrosis in PA. The measured index of myocardial fibrosis has functional impact on the LV diastolic function.