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Abstract #0639

Cortical Depth Dependent Temporal Dynamics of the BOLD Response in the Human Brain

Jeroen Cornelis Willem Siero1,2, Natalia Petridou1,2, Johannes Marinus Hoogduin1,2, Peter R. Luijten2, Nick F. Ramsey1

1Rudolf Magnus Institute, University Medical Center Utrecht, Utrecht, Netherlands; 2Radiology, University Medical Center Utrecht, Utrecht, Netherlands

The BOLD specificity to the cortical vascular architecture was investigated in the human brain, at 7T: temporal dynamics (delay and width) of the BOLD response were characterized across cortical depth in the primary motor and visual cortices. Faster and narrower (<4s) BOLD responses corresponded to the deeper gray matter, and these temporal properties increased in an orderly manner toward the cortical surface. A pooling time of oxygenated blood from the deeper cortex to the pial surface was estimated <~1s. These findings matched the known vascular organization across cortical depth, and may lead to new insights in neurovascular coupling in humans.