Ralph E. Hurd1, Daniel Spielman2, Sonal Josan3, Yi-Fen Yen1, Adolf Pfefferbaum3,4, Dirk Mayer2,3
1GE Healthcare, Menlo Park, CA, USA; 2Department of Radiology, Stanford University, Stanford, CA, USA; 3Neuroscience Program, SRI International, Menlo Park, CA, USA; 4Psychiatry & Behavioral Sciences, Stanford University, Stanford, CA, USA
Three-dimensional dynamic metabolic images were obtained following injection of 80 mM hyperpolarized [1-13C]pyruvate, prepared with, and without, 40 mM sodium lactate in the dissolution buffer. Comparisons were made on the basis of apparent rate constants, lactate signal, and contrast-to-noise ratio. In a second experiment, metabolic images of hyperpolarized 40 mM [1-13C]lactate, were compared, with and without 80 mM sodium pyruvate in the dissolution buffer. This set of exchange-linked dissolution agents and controls was investigated as a potential quantitative measure of steady-state pool size limits and isotopic exchange, as well as for improvement in metabolic imaging signal and contrast-to-noise ratio.