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Abstract #0681

T2-VBM is More Sensitive to Alzheimers Disease Pathology Than Conventional T1-VBM

Julio Acosta-Cabronero1, Lara Z. Diaz-de-Grenu1, Joao MS Pereira1, George Pengas1, Guy B. Williams1, Peter J. Nestor1

1Department of Clinical Neurosciences, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom

In this study we tested the hypothesis that voxel-based morphometry (VBM) using the recently-developed T2-weighted SPACE acquisition would be more sensitive to grey matter pathology in Alzheimers disease (AD) than conventional T1-VBM using MPRAGE images with the same resolution. The distribution of abnormalities identified by T2-VBM, but not with T1-VBM, bore a striking resemblance to the distribution of amyloid plaque deposition in AD. This study demonstrates that T2-VBM is more sensitive to histopathological brain changes than the conventional T1-VBM method.