Mark David Meadowcroft1, 2, Zachary George Herse1, James R. Connor3, Qing X. Yang1
1Radiology - Center for NMR Research, Pennsylvania State University - College of Medicine, Hershey, PA, USA; 2DMCP - Neuroimaging, Bristol-Myers Squibb, Wallingford, CT, USA; 3Neurosurgery, Pennsylvania State University - College of Medicine, Hershey, PA, USA
Our previous research illuminated that transverse relaxation and contrast related to Aβ plaques seen in T2* weighted images are associated with plaque morphology and iron content. The fibrillar organization and macromolecule architecture of Aβ plaques presents an ideal setting for the usage of magnetization transfer (MT) imaging to view tightly bond protons on the surface of component fibrils in the Aβ plaques. The data demonstrate the detailed MT associated with individual plaques and the different MT ratios of Aβ ROIs compared to surrounding tissue. To our knowledge, this data represents the first MT imaging of individual Aβ plaques.