Lindsay K. Hill1, Karen C. Briley-Saebo2, Dung M. Hoang1, Asad Baig1, Brian J. Nieman3, Zahi A. Fayad2, Youssef Z. Wadghiri1
1Radiology, New York University School of Medicine, New York, NY, USA; 2Radiology, Mount Sinai School of Medicine, New York, NY, USA; 3Mouse Imaging Centre, Hospital for Sick Children, Toronto, Canada
There is increasing evidence that neurovascular dysfunction may be a very important risk factor in the development of Alzheimers Disease, an age-related condition. We utilized recently developed Gd-loaded micelles to achieve (100um)3 MR angiograms. Our approach was used to monitor 3D neurovascular changes in individual C57BL/6 wild type mice over one year of normal aging in order to establish a baseline for future research on age-dependent diseases such as Alzheimers Disease.