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Abstract #0702

Tensor Based Morphometry on the Tc1 Mouse Model of Down Syndrome Highlights Previously Undetected Phenotypes

Benjamin Sinclair1,2, Jon Cleary2, Marc Modat1, Francesca Norris2,3, Frances Wiseman4, Victor Tybulewicz5, Elizabeth Fisher4, Mark Lythgoe2, Sebastien Ourselin1

1Centre for Medical Image Computing, UCL, London, United Kingdom; 2Centre for Advanced Biomedical Imaging, UCL, London, United Kingdom; 3Centre for Mathematics & Physics in the Life Sciences & Experimental Biology (CoMPLEX); 4UCL, Institute of Neurology, London, United Kingdom; 5MRC National Institute for Medical Research, London, United Kingdom

This study investigates the neurological characteristics of the Tc1 mouse model of Down syndrome using tensor based morphometry.