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Abstract #0705

Amide Proton Transfer (APT) MR Signal As a Novel Imaging Biomarker for Charactering Radiation Necrosis in Rats

Silun Wang1, Erik Tryggestad2, Michael Armour2, Eric Ford2, Tingting Zhou1, Kun Yan1, Zhibo Wen1, Peter C. M. van Zijl1,3, Jinyuan Zhou1,3

1Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; 2Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; 3F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute


We evaluated radiation-induced necrosis in a rat model (40 Gy, 1010 mm2) using a multi-parametric MRI protocol, including diffusion, perfusion, and amide proton transfer (APT) imaging. Results showed that radiation necrosis consisted of a hypointense central zone and an iso-intense to slightly hyperintense peripheral zone on APT imaging, which reflected coagulative necrosis and reactive brain tissue, respectively. APT imaging can provide useful diagnostic information to assess radiation necrosis.