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Abstract #0707

Respiratory Triggered Chemical Exchange Saturation Transfer MRI for pH Mapping in the Kidneys at 3T

Jochen Keupp1, Edwin Heijman2, Sander Langereis2, Holger Grll2, Dario L. Longo3, Enzo Terreno3, Silvio Aime3

1Philips Research Europe, Hamburg, Germany; 2Philips Research Europe, Eindhoven, Netherlands; 3Center for Molecular Imaging, University of Turino, Turino, Italy

A local MR pH measurement would be of high clinical interest, because several pathologies are associated with pH changes (i.e., tumors, renal diseases). CEST-MRI is promising, e.g. using Iopamidol as contrast agent, which exhibits two amide proton pools for a ratiometric pH measure independent of concentration. Existing CEST methodology was extended to anatomical regions affected by physiological motion by using a breathing triggered technique with continuous pulsed RF saturation during the wait time for the trigger event. Feasibility of motion compensated pH mapping in the kidneys of a rat could be demonstrated on a clinical 3T scanner.