Jochen Keupp1, Edwin Heijman2, Sander Langereis2, Holger Grll2, Dario L. Longo3, Enzo Terreno3, Silvio Aime3
1Philips Research Europe, Hamburg, Germany; 2Philips Research Europe, Eindhoven, Netherlands; 3Center for Molecular Imaging, University of Turino, Turino, Italy
A local MR pH measurement would be of high clinical interest, because several pathologies are associated with pH changes (i.e., tumors, renal diseases). CEST-MRI is promising, e.g. using Iopamidol as contrast agent, which exhibits two amide proton pools for a ratiometric pH measure independent of concentration. Existing CEST methodology was extended to anatomical regions affected by physiological motion by using a breathing triggered technique with continuous pulsed RF saturation during the wait time for the trigger event. Feasibility of motion compensated pH mapping in the kidneys of a rat could be demonstrated on a clinical 3T scanner.