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Abstract #0724

Assessment of Left Ventricular 2D Pseudo Flow Pathway during Early Diastole using SPAMM-PAV

Ziheng Zhang1, Donald P. Dione2, Ben A. Lin2, Albert J. Sinusas2, Smita Sampath1

1Department of Diagnositc Radiology, Yale University, School of Medicine, New Haven, CT, USA; 2Section of Cardiovascular Medicine, Yale University, School of Medicine, New Haven, CT, USA

Early diastolic filling is tightly coupled to regional myocardial relaxation patterns. Here, we track the 2D pseudo pathlines of blood emitter particles that are dynamically released from the mitral valve plane during early diastole. Results in normal volunteers demonstrate a distinct pattern of filling that corresponds closely with myocardial relaxation patterns. Further, results in an infarcted animal demonstrate significant abnormality, underlining the sensitivity of this method as an indicator of diastolic filling abnormalities.