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Abstract #0782

Multi Modal MRI Reveals Early Life Brain Changes in Human Apoe-Ε4 Carriers

Ory Levy1, Anat Bar-Shira2, Avi Orr-Urtreger2,3, Yaniv Assaf1

1Department of Neurobiology, Life Sciences Faculty, Tel aviv University, Tel Aviv, Israel; 2The Genetic Institute, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel; 3The Sackler Faculty of Medicine, Tel aviv University, Tel Aviv, Israel

Carriers of APOE-4 allele have a 2-3 fold risk of developing Alzheimer's. difference in APOE4 brain structure are known for 50 years old, and for glucose metabolism in 20 years old normal subjects. Here, 52 healthy Ashkenazi Jews (ages 20-35), were genotyped and underwent MRI protocol including DTI, T1 and T2. ANOVA statistics revealed that T1 VBM and DTI and T2maps VBA indicate significant differences between APOE33\23 (29,8) and APOE34 (11) in the parahippocampal gyrus, the hippocampus and the globus pallidus, the orbitofrontal cortex, and the dorsolateral prefrontal cortex. Our findings implicate that APOE affects the brain since developmental stages.