Kyrre E. Emblem1,2, Kim Mouridsen1, Ronald J. H. Borra1, Gregory Sorensen1, Tracy T. Batchelor3, Rakesh K. Jain4, Atle Bjornerud2,5
1A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA; 2The Interventional Center, Oslo University Hospital - Rikshospitalet, Oslo, Norway; 3Pappas Center for Neuro-Oncology, Massachusetts General Hospital, Boston, MA, USA; 4Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA; 5Department of Physics, University of Oslo, Oslo, Norway
A byproduct of DSC-based leakage correction methods is the leakage term reflecting estimated contrast agent extravasation into the interstitial space. Potentially, if properly understood and corrected for, this parameter could provide estimates similar to that of DCE Ktrans. In this study, we have compared contrast agent extravasation from DSC and DCE using simulations and patient data.