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Abstract #0797

Assessment of Liver Fibrosis in Rats with MR Imaging & Elastography

Heiko G. Niessen1, Michael Neumaier1, Thomas Kaulisch1, Ingolf Sack2, Dieter Klatt3, Thomas Klein4, Juergen Braun3, Detlef Stiller1

1In-Vivo Imaging, Target Discovery Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany; 2Dept. of Radiology, Charite-University Medicine Berlin; 3Dept. of Medical Informatics, Charite-University Medicine Berlin; 4CardioMetabolic Diseases Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany

Magnetic Resonance Elastography (MRE) is a promising tool to distinguish steatohepatosis from fibrosis and to differentiate various stages of fibrosis. Here, rats were fed with a combined methionine-choline-deficient (MCD) and high-fat diet (HFD) to induce liver fibrosis. Age-dependent alterations were investigated with MRE, imaging (T2, ADC), and spectroscopy. For MRE a newly developed hydraulic-based actuator was used. MRE yields a significantly different storage and loss modulus in the rat liver after MCD/HF-diet. In addition, T2 is significantly increased, the ADC reduced compared to control animals. However, the magnitude of the latter effects is smaller than those obtained with MRE.