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Abstract #0806

In Vivo Application of Breath-Hold Single-Voxel 1H Spectroscopy for T2-Corrected Hepatic Lipid Measurement: Evaluation of Accuracy & Reproducibility

Puneet Sharma1, Hiroumi D. Kitajima1, Xiaodong Zhong2, Bobby Kalb3, Alton B. Farris4, Miriam B. Vos5, Diego R. Martin3

1Radiology, Emory Healthcare, Atlanta, GA, United States; 2MR R&D Collaborations, Siemens Healthcare, Atlanta, GA, United States; 3Radiology, Emory University, Atlanta, GA, United States; 4Pathology, Emory University, Atlanta, GA, United States; 5Hepatology, Children's Hospital of Atlanta, Atlanta, GA, United States

Therapy development for early disease has required accurate and reproducible measurement for the longitudinal monitoring of hepatic lipid. Recently, a multi-echo breath hold T2-corrected MR spectroscopy technique (HISTO-MRS) has demonstrated clinical feasibility, while proving robust in phantom validation of lipid content. This investigation extends these initial observations for a more broad evaluation of accuracy and reproducibility in a clinical setting. The results showed that the HISTO technique was highly reproducible, while significantly correlating with biopsy measures, allowing effective longitudinal assessment of hepatic lipid. Combined with efficient and automated post-processing steps, HISTO-MRS demonstrates clinical applicability as a biopsy surrogate.