Abstract #0818

Comparison of ASL & DCE-MRI for Renal Perfusion Measurements

Jeff D. Winter^1,2, Keith S. St. Lawrence^3,4, Hai-Ling Margaret Margaret Cheng^1,5

¹Physiology & Experimental Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada; ²Research & Development, IMRIS, Winnipeg, Manitoba, Canada; ³Imaging Division, Lawson Research Institute, London, Ontario, Canada; ⁴Medical Biophysics, University of Western Ontario, London, Ontario, Canada; ⁵Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

The injury or loss of renal microvessels is a determinant of renovascular disease severity. Assessment of renal microvasculature may be achieved using MR perfusion techniques including quantitative DCE and ASL. This study compared renal perfusion estimates for ASL and DCE MRI. DCE MRI was performed with a dual-bolus contrast injection for improved arterial input sampling. We found DCE estimates of renal cortex perfusion (3.57 0.96 ml/g/min) were in agreement with ASL (3.28 0.59 ml/g/min). Moreover, this study showed feasibility of the dual bolus approach for quantitative DCE for the first time outside of cardiac imaging.