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Abstract #0843

Reliability Analysis of Liver Apparent Diffusion Coefficient Measurement: Importance of ROI Size & Image Threshold

Mamak Eatesam1, Michelle Nystrom1, Susan M. Noworolski1,2, Jennifer L. Dodge3, Raphael B. Merriman4, Aliya Qayyum1

1Radiology & Biomedical Imaging, UCSF, San Francisco, CA, United States; 2Graduate Group in Bioengineering, UC San Francisco & Berkeley, San Francisco & Berkeley, CA, United States; 3Department of Internal Medicine, UCSF, Fresno, CA, United States; 4Department of Medicine, California Pacific Medical Center, San Francisco, CA, United States

The repeatability of liver ADC measurement was compared across different image analysis techniques designed to reduce the impact of vessels on the ADC. Two successive breath-hold DWI scans were performed in 14 subjects; 6 NAFLD and 8 healthy volunteers. ADC was derived from 6 small and 3 large ROIs and with 4 different image threshold applications. Results indicated that large ROI ADC measurements were more repeatable than small ROI measurements. Vessel correction was associated with the narrowest range of ADC difference between scans, suggestive of highest repeatability.