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Abstract #0858

Reproducibility & Diagnostic Accuracy of In Vivo Proton Magnetic Resonance Spectroscopy in Detection of Hepatic Steatosis

Jing Qi1, Mithat Gnen2, Jinru Shia3, Lawrence Schwartz4, Nancy Kemeny5, Michael D'Angelica6, Yuman Fong6, Jason Koutcher1, Kristen Zakian1

1Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, NY, United States; 2Epidemiology-Biostatistics, Memorial Sloan-Kettering Cancer Center; 3Pathology, Memorial Sloan-Kettering Cancer Center; 4Radiology, Columbia University Medical School; 5Medicine, Memorial Sloan-Kettering Cancer Center; 6Surgery, Memorial Sloan-Kettering Cancer Center

To assess the reproducibility of hepatocellular triglyceride content measurements on a 1.5T scanner using 1H MRS during a single breath-hold, 16 heathy adults were studied twice with a 2 week interval. The intra- and inter- examination coefficients of variance were 6% and 15% respectively. To evaluate the accuracy of 1H MRS in quantitation of HTGC, fat/(fat+water) (FFW) from 16 colorectal cancer patients was correlated with liver histology. A positive correlation (r = 0.78, P < 0.001) was observed between FFW and histology steatosis grade. A FFW cutoff value of 0.025 results in 86% sensitivity and 89% specificity for detection of clinically relevant steatosis.