Qing Yuan1, Ivan Dimitrov2, Naim M. Maalouf3, Khashayar Sakhaee3, Paul T. Weatherall1
1Radiology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, United States; 2Philips Medical Systems, Cleveland, OH, United States; 3Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, United States
Noninvasive measurement of renal cortical fat content can potentially determine the degree of renal fat accumulation in various kidney disorders. The goal of this study was to develop a technique to perform in vivo 1H MRS in human kidney at 3T and to establish nominal values of fat content in normal volunteers. A respiratory-triggered non-water suppressed single-voxel PRESS sequence with TE-averaging was used to reduce motion and sideband artifacts. No fat content was detected from kidney parenchyma in healthy subjects. Voxel placement was crucial since including perirenal or hilar fat within the kidney resulted in fat contamination of the spectra.