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Abstract #0896

Ventilation Strategy to Minimize the Effect of Residual Gas Volume on ADC in Rat Lungs

Laura Carrero-Gonzalez1,2, Thomas Kaulisch1, Jesus Ruiz-Cabello2,3, Jose Manuel Perez-Sanchez4, German Peces-Barba5, Detlef Stiller1, Ignacio Rodriguez2,3

1Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Baden-Wrttemberg, Germany; 2Universidad Complutense de Madrid, Madrid, Spain; 3CIBER de Enfermedades Respiratorias, Madrid, Spain; 4Unit de Recherche en Rsonance Magntique Mdicale (UMR 8081), Univ.Paris-Sud, CNRS, Orsay, France; 5Fundacin Jimnez-Daz, Madrid, Spain

Apparent diffusion coefficient (ADC) of HP-gases is a parameter that reflects changes in lung microstructure but it depends on many physiological and experimental variables. The application of a positive end expiratory pressure (PEEP) causes an increase of the residual volume. If incoming and residual gases do not have similar diffusion coefficient, the obtained ADC values will be affected. A proposed single breath-hold protocol uses 4He-O2 for ventilation and HP3He-N2 for imaging. Both gas mixtures have a very similar diffusion coefficient. ADCs obtained from the proposed strategy show to be independent of PEEP, thus minimizing the effect of the different residual volumes.