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Abstract #0899

Quantitative Imaging of Alveolar Recruitment with Hyperpolarized Gas MRI

Maurizio F. Cereda1, Kiarash Emami2, Stephen J. Kadlecek2, Yi Xin2, Puttisarn Mongkolwisetwara2, Harilla Profka2, Amy Barulic2, Stephen Pickup2, Nicholas N. Kuzma2, Masaru Ishii3, Hooman Hamedani2, Benjamin M. Pullinger2, Rajat Ghosh2, Jennia Rajaei2, Clifford S. Deutschman1, Rahim R. Rizi2

1Anesthesiology & Critical Care, University of Pennsylvania, Philadelphia, PA, United States; 2Radiology, University of Pennsylvania, Philadelphia, PA, United States; 3OtolaryngologyHead & Neck Surgery, Johns Hopkins University, Baltimore, MD, United States

Atelectasis, often caused by a mechanical ventilator, promotes lung injury, whose mechanisms are not fully understood. Understanding these underlying mechanisms requires simultaneous measurements of ventilated air space and alveolar size, which can be achieved through the use of hyperpolarized gas MRI technology. Additionally, this technique can show how alveolar recruitment maneuvers reestablish a normal pattern of airspace inflation.