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Abstract #0914

Quantification of Aerosol Deposition in the Upper Airways: A Multimodality Study

Mathieu Sarracanie1, Denis Grebenkov2, Soule Coulibaly1, Andrew Martin3, Kyle Hill4, Jose Manuel Perez-Sanchez1, Redouane Fodil5, Lionel Martin1, Emmanuel Durand1, Georges Caillibotte3, Daniel Isabey5, Luc Darrasse1, Jacques Bittoun1, Xavier Maitre1

1IR4M (UMR8081), Univ Paris-Sud, CNRS, Orsay, France; 2Laboratoire de Physique de la Matiere Condensee (UMR7643), Ecole Polytechnique, CNRS, Palaiseau, France; 3Centre de Recherche Claude Delorme (CRCD), Air Liquide, Les Loges-en-Josas, France; 4Radiology Research Group, Oxford MRI Centre, Oxford University, Oxford, United Kingdom; 5Biomecanique Cellulaire et Respiratoire (U955), IMRB, Inserm, Creteil, France

One of the key challenges in the study of health-related aerosols is predicting and monitoring sites of particle deposition in the airways. Recent work in MRI has shed light on techniques to quantify magnetic particles in living bodies by the measurement of associated static magnetic field variations. Dealing with lung MRI, hyperpolarized helium-3 may be used to compensate for the lack of signal in the airways, so as to allow assessment of pulmonary function and morphology. In the present work, aerosol deposition in a mouth-throat phantom measured using helium-3 MRI was correlated with computational fluid dynamics simulations and gamma scintigraphy.