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Abstract #0927

Block Paradigm Optimization for Dynamic Oxygen-Enhanced MRI of the Lung

Olaf Dietrich1, Michael Ingrisch1, Michael Peller1, Konstantin Nikolaou, Maximilian F. Reiser,1

1Josef Lissner Laboratory for Biomedical Imaging, Department of Clinical Radiology, Ludwig Maximilian University of Munich, Munich, Germany

Several different block paradigms with different numbers of blocks (of oxygen and room air administration) and different block durations have been used in oxygen-enhanced MRI (O2-MRI) of the lung. The purpose of this study was to compare different block paradigms in simulations based on parameters taken from measurements in 11 volunteers to find the optimal design for the evaluation of dynamic O2-MRI data, i.e. for pixelwise fitting of the signal enhancement and the wash-in/out times. Optimal results were obtained with 15 baseline scans (breathing air), followed by 50 scans breathing pure oxygen and by 15 final scans breathing air.