Characterization of Liver Fibrosis by 1H- & 31P-MRS in CCl4-Treated Rats

Yunjung Lee¹, Hyungjoon Noh¹, Keunhyung Kang¹, Ok-Hee Kim¹, Byung-Chul Oh¹, Hyeonjin Kim²

Liver fibrosis was characterized in CCl4-treated rats by using both 1H- and 31P-MRS, and the potential diagnostic efficacy of the technique was evaluated. The differentiation between the three animal groups of control, F1-2 and F3-4 in this study was achieved only if the combination of the 1H- and 31P-MRS measures was used. Therefore, our study demonstrates the advantage and feasibility of using both 1H- and 31P-MRS techniques in the assessment of liver fibrosis in vivo.