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Abstract #0944

Characterization of Liver Fibrosis by 1H- & 31P-MRS in CCl4-Treated Rats

Yunjung Lee1, Hyungjoon Noh1, Keunhyung Kang1, Ok-Hee Kim1, Byung-Chul Oh1, Hyeonjin Kim2

1Lee Gil Ya Cancer & Diabetes Institute, Gachon University of Medicine & Science, Incheon, Korea, Republic of; 2Radiology, Seoul National University Hospital, Seoul, Korea, Republic of

Liver fibrosis was characterized in CCl4-treated rats by using both 1H- and 31P-MRS, and the potential diagnostic efficacy of the technique was evaluated. The differentiation between the three animal groups of control, F1-2 and F3-4 in this study was achieved only if the combination of the 1H- and 31P-MRS measures was used. Therefore, our study demonstrates the advantage and feasibility of using both 1H- and 31P-MRS techniques in the assessment of liver fibrosis in vivo.