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Abstract #0946

Imaging of Hepatic Steatosis & Hyperpolarized Carbon Metabolism at 14T - Applications to a Murine Model of Non-Alcoholic Fatty Liver Disease

Andrew G. Taylor1, Kayvan Keshari1, Robert Bok1, Subramaniam Sukumar1, Aliya Qayyum1, John Kurhanewicz1

1Radiology & Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States

Non-Alcoholic Fatty Liver Disease (NAFLD) is a very common cause of chronic liver disease, however understanding of metabolic abnormalities and prognostic indicators in NAFLD is limited. In vivo studies of hepatic metabolism in a mouse model of NAFLD were performed at 600MHz using copolarized [1-13C]-pyruvate and 13C-urea. An interleaved fat- and water-sensitive sequence, used to monitor disease progression, correlated well with extent of steatosis on subsequent histology. No significant change in hepatic pyruvate metabolism was identified in NAFLD mice relative to control, consistent with published work suggesting hypermetabolism in this model results from increased lipid flux through β-oxidation.