Meeting Banner
Abstract #0963

Localized Hypoxia Results in Spatially Heterogeneous Metabolic Signatures in Breast Tumor Models

Lu Jiang1, Dmitri Artemov1, Paul Winnard Jr.1, Venu Raman1, Zaver Bhujwalla1, Kristine Glunde1

1ICMIC, Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins Medical School, Baltimore, MD, United States

Tumor hypoxia triggers signaling cascades that significantly impact on biological outcomes resulting in resistance to radio- and chemotherapy. Therefore, understanding the hypoxic response of tumors is critical. In this study, we have investigated the relationship between hypoxia, necrosis and several metabolites in a human breast cancer model by combining in vivo magnetic resonance imaging (MRI), magnetic resonance spectroscopic imaging (MRSI) with optical imaging of hypoxia and necrosis ex vivo. This multi-modal molecular imaging technology proved useful for delineating the effects of tumor hypoxia and necrosis on MRS-detectable metabolites, some of which may serve as markers for hypoxia and/or necrosis.