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Abstract #0968

Evaluation of MR Imaging Biomarkers of the Infiltrative & Vascular Phenotype in Orthotopic Murine RG2 Gliomas

Jessica K. R. Boult1, Lara Perryman2, Gary Box3, Chris Jones2, Suzanne A. Eccles3, Simon P. Robinson1

1Cancer Research UK & EPSRC Cancer Imaging Centre, The Institute of Cancer Research & Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom; 2Paediatric Oncology, The Institute of Cancer Research, Sutton, Surrey, United Kingdom; 3Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, Sutton, Surrey, United Kingdom

Delineation of infiltrative gliomas, in which the blood brain barrier remains intact, using conventional Gd-DTPA-enhanced MRI can be problematic. The use of intravascular USPIO contrast agents may facilitate the detection of such infiltrative areas. In this study, quantitative Gd-DTPA and USPIO-enhanced MRI was performed in orthotopically propagated RG2 gliomas and the spatial relationship compared. Tumours were highly heterogeneous and a displayed a substantially higher blood volume than the surrounding brain. An association between R1 with USPIO and fractional blood volume established with USPIO was observed. Regions of infiltration identified histologically presented with a relatively low blood volume and low R1.