Xiaobing Fan1, Sanaz A. Jansen2, Erica J. Markiewicz1, Gillian M. Newstead1, Gregory S. Karczmar1
1Radiology, The University of Chicago, Chicago, IL, United States; 2Mouse Cancer Genetics Program, National Cancer Institute, Frederick, MD, United States
Clinical DCE-MRI is less sensitive to ductal carcinoma in situ (DCIS) than invasive breast cancer. This could be because region-of-interest (ROI) analysis is generally used in clinical practice to improve signal-to-noise ratio. Here we performed pixel-by-pixel analysis of contrast media uptake by pure intraductal cancers in a mouse model of breast cancer and compared this approach with ROI-based analysis. DEC-MRI data were acquired at 4.7T with temporal resolution of ~4 s. Contrast uptake by intraductal cancers was heterogeneous compared to lymph nodes and there was a significant difference between pixel-based analysis and whole ROI analysis.