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Abstract #0970

Distribution of DCE-MRI Pharmacokinetic Parameter Maps in Early Murine Mammary Cancer

Xiaobing Fan1, Sanaz A. Jansen2, Erica J. Markiewicz1, Gillian M. Newstead1, Gregory S. Karczmar1

1Radiology, The University of Chicago, Chicago, IL, United States; 2Mouse Cancer Genetics Program, National Cancer Institute, Frederick, MD, United States

Clinical DCE-MRI is less sensitive to ductal carcinoma in situ (DCIS) than invasive breast cancer. This could be because region-of-interest (ROI) analysis is generally used in clinical practice to improve signal-to-noise ratio. Here we performed pixel-by-pixel analysis of contrast media uptake by pure intraductal cancers in a mouse model of breast cancer and compared this approach with ROI-based analysis. DEC-MRI data were acquired at 4.7T with temporal resolution of ~4 s. Contrast uptake by intraductal cancers was heterogeneous compared to lymph nodes and there was a significant difference between pixel-based analysis and whole ROI analysis.