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Abstract #0978

DMSO-Based Contrast as a Potential Intermediate Endpoint Biomarker of GBM Response to Therapy.

Teresa Delgado-Goi1,2, Juana Martin-Sitjar1,2, Rui V. Simes1,2, Milena Acosta1,2, Silvia Lope-Piedrafita2,3, Carles Ars1,2

1Bioquimica i Biologia Molecular, Universitat Autnoma Barcelona, Cerdanyola del Valls, Barcelona, Spain; 2Centro de Investigacin Biomdica en Red en Bioingeniera, Biomateriales y Nanomedicina (CIBER-BBN), Cerdanyola del Valls, Barcelona, Spain; 3Servei de Ressonncia Magntica Nuclear, Universitat Autnoma de Barcelona, Cerdanyola del Valles, Barcelona, Spain

Dimethyl Sulfoxide (DMSO) is a common administration vehicle for some drugs, such as temozolomide (TMZ). DMSO has been reported to cross the blood-brain-barrier and to produce contrast, detected by 1H MRS/MRSI, between GL261 mouse glioblastoma (GBM) and nearby/peritumoral brain parenchyma. This work evaluates the effect of TMZ in mouse GBM progression, which can be monitored by T2w MRI as a transient volume growth arrest. MRSI-detection of differential DMSO accumulation in GL261 treated with respect to non-treated tumours provides a non-invasive biomarker of this response.