Abstract #0980

Multi-Parametric MRI Assessment of the Anti-Angiogenic Effects of Liposome-Encapsulated Glucocorticoids

Ewelina Kluza¹, Marieke Heisen², Sophie Schmid¹, Daisy W. J. van Der Schaft³, Raymond M Schiffelers⁴, Gert Storm⁴, Bart M. ter Haar Romeny², Gustav J. Strijkers¹, Klaas Nicolay¹

¹Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands; ²Biomedical Image Analysis, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands; ³Biomechanics & Tissue Engineering, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands; ⁴Department of Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands

Liposome-incorporated glucocorticoids (GC) are known for their tumor growth inhibitory effects. The mechanism by which this occurs is largely unknown. The present study sought to test the hypothesis that liposomal GC activity involves inhibition of tumor angiogenesis. To that aim, dynamic contrast enhanced (DCE)-MRI was used to probe vascular function in B16F10 tumors, grown s.c. in C57BL/6 mice. DCE-MRI data were fitted with the two-compartment Tofts model. In addition, T2- and DW-MRI and histopathology were used. GC treatment caused a significant reduction in Ktrans from day 2 post-therapy and prevented the ADC reduction seen in non-treated tumors.